Phases of Clinical Trials

Phases of clinical trials: Phase 0 Phase 0 is a recent designation for exploratory, first-in-human trials conducted in accordance with the United States Food and Drug Administration’s (FDA) 2006 Guidance on Exploratory Investigational New Drug (IND) Studies....

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Dietary Supplement Greatly Extends Worm Life Span

Drug seems to mimic the biological effects of calorie restriction, letting worms live up to 70 percent longer. By Virginia Hughes, for National Geographic PUBLISHED MAY 14, 2014 A light micrograph of Caenorhabditis elegans, a soil-dwelling nematode often used in...

Alpha-Ketoglutarate: Physiological Functions and Applications

Alpha-Ketoglutarate: Physiological Functions and ApplicationsNan Wu, Mingyao Yang, Uma Gaur, Huailiang Xu, Yongfang Yao, and Diyan Li* Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism....

Targets for future drugs of AD

The hope for future drugs Currently, there are five FDA-approved Alzheimer’s drugs that treat the symptoms of Alzheimer’s — temporarily helping memory and thinking problems — with a sixth drug available globally. But these medications do not treat the...

HUP on memory in AD

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer’s disease. Abstract AIM: To evaluate the efficacy and safety of tablet huperzine-A (Hup) in patients with Alzheimer’s disease. METHODS: Using multicenter, prospective,...